Volume 2 (Issue 1)

pp. 1-12

Open Access

Review paper

Spice Bioactive Compounds versus Lifestyle Disorders

Uma Maheshwari Srinivasa, Madeneni Madhava Naidu*

UMS, MMN: Department of Spices and Flavor Sciences, CSIR-CFTRI, Mysuru - 570020, Karnataka, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad - 201002, UP, India

*Corresponding author: Madeneni Madhava Naidu; Email: mmnaidu@cftri.res.in



22 January 2022


04 March 2022

Cite as: Srinivasa, U. M,  Naidu, M. M. (2022). Spice Bioactive Compounds versus Lifestyle Disorders. Inventum Biologicum, 2 (1), 1-12.


Spices play a significant role in food flavoring and as adjuncts in traditional medicine. Recent developments have shown that the spice extracts and their bioactive molecules play a vital part in either preventing, ameliorating or curing different diseases or disorders. Lifestyle diseases have increased globally and are a significant public health challenge to every country. Cardiovascular diseases and cancer, the first and second leading cause of death, respectively, and diabetes and obesity, are on par through the exponential increase in the incidents. Though pharmaceuticals strive hard to be active and efficient, their synergistic effect makes them partially unreliable. This surges the need for natural therapeutic medicines to outmaneuver the existing global health burden. Hence, nutrition-based medicine is the present vogue used to target the pathogeny and their complications. Here we illustrate the most critical investigations which have been validated to be potential in combating these complications through rhizome spice (turmeric and ginger), seed spice (fenugreek), seed/leaf spice (coriander) and their bioactive components. Drug safety is also the primary concern of medical therapy; hence the usage is recommended in the safety range without surpassing the toxicity levels. Nutraceuticals and functional foods are a promising source of natural medicines for controlling various health complications used in proper concentrations and methods. In this paper, selective spices and their effects and the mechanisms of action taken by them to circumvent the significant lifestyle diseases have been discussed.


Coriander, Fenugreek, Ginger, Lifestyle diseases, Safety, Spices, Turmeric


  1. Aburjai, T.; Natsheh, F. M. Plants Used in Cosmetics. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 2003, 17 (9), 987-1000.

  2. Ahmad, R. S.; Hussain, M. B.; Sultan, M. T.; Arshad, M. S.; Waheed, M.; Shariati, M. A.; Plygun, S.; Hashempur, M. H. Biochemistry, Safety, Pharmacological Activities, and Clinical Applications of Turmeric: A Mechanistic Review. Evidence-Based Complementary and Alternative Medicine, 2020, 2020 (article ID 7656919), 1-14.

  3. Akash, M. S. H.; Rehman, K.; Tariq, M.; Chen, S. Zingiber officinale And Type 2 Diabetes Mellitus: Evidence from Experimental Studies. Critical Reviews in Eukaryotic Gene Expression, 2015, 25 (2), 91-112.

  4. Alappat, L.; Awad, A. B. Curcumin and Obesity: Evidence and Mechanisms. Nutrition reviews, 2010, 68 (12), 729-738.

  5. Ali, B. H.; Blunden, G.; Tanira, M. O.; Nemmar, A. Some Phytochemical, Pharmacological and Toxicological Properties of Ginger (Zingiber officinale Roscoe): A Review of Recent Research. Food and chemical Toxicology, 2008, 46 (2), 409-420.

  6. Al-Yahya, A. A. Reproductive, Cytological and Biochemical Toxicity of Fenugreek in Male Swiss Albino Mice. African Journal of Pharmacy and Pharmacology, 2013, 7 (29), 2072-2080.

  7. Asai, A.; Miyazawa T. Dietary Curcuminoids Prevent High Fat Diet Induced Lipid Accumulation in Rat Liver and Epididymal Adipose Tissue. Journal of Nutrition, 2001, 131, 2932-2935.

  8. Badr, O. M.; Sakr, S. A.; Abd-Eltawab, H. M. Ameliorative Effect of Ginger Extract Against Pathological Alterations Induced in Mice Bearing Solid Tumors. Journal of. Bioscience and Applied Research, 2016, 2, 185-196.

  9. Cho, S. Y.; Jun, H. J.; Lee, J. H.; Jia, Y.; Kim, K. H.; Lee, S. J. Linalool Reduces The Expression of 3-Hydroxy-3-Methylglutaryl CoA Reductase via Sterol Regulatory Element Binding Protein-2-And Ubiquitin-Dependent Mechanisms. FEBS Letters, 2011, 585 (20), 3289-3296.

  10. Chuengsamarn, S.; Rattanamongkolgul, S.; Luechapudiporn, R.; Phisalaphong, C.; Jirawatnotai, S. Curcumin Extract for Prevention of Type 2 Diabetes. Diabetes care, 2012, 35 (11), 2121-2127.

  11. Day, T. W.; Huang, S.; Safa, A. R. c-FLIP Knockdown Induces Ligand-Independent DR5-, FADD-, Caspase-8-, and Caspase-9-Dependent Apoptosis in Breast Cancer Cells. Biochemical Pharmacology, 2008, 76 (12), 1694-1704.

  12. Deepa, B.; Anuradha, C. V. Linalool a Plant Derived Monoterpene Alcohol, Rescues Kidney from Diabetes-Induced Nephropathic Changes via Blood Glucose Reduction. Diabetologia Croatica, 2011, 40 (4), 121-137.

  13. Deshpande, P.; Mohan, V; Thakurdesai, P. Preclinical Safety Assessment of Glycosides Based Standardized Fenugreek Seeds Extract: Acute, Sub-chronic Toxicity and Mutagenicity Studies. Journal of Applied Pharmaceutical Science, 2016, 6 (9), 179-188.

  14. Dhillon, N.; Aggarwal, B. B.; Newman, R. A.; Wolff, R. A.; Kunnumakkara, A. B.; Abbruzzese, J. L. Phase - II Trial of Curcumin in Patients with Advanced Pancreatic Cancer. Clinical Cancer Research, 2008, 14, 4491-4499.

  15. Fahmy, H. A.; Shreif, N. H.; Gharib, O. A. The Protective Effect of Coriandium Sativum Extract on Hepato-Renal Toxicity Induced in Irradiated Rats. European Journal of Medicinal Plants, 2014, 4 (2), 196-205.

  16. Faizal, I. P; Suresh, S.; Satheesh Kumar, R.; Augusti, K. T. A Study on The Hypoglycemic and Hypolipidemic Effects of An Ayurvedic Drug Rajanya-malakadi in Diabetic Patients. Indian Journal of Clinical Biochemistry, 2009, 24, 82-87.

  17. Fuller, S.; Jacqueline, M. S. Diosgenin, 4-Hydroxyisoleucine, and Fiber from Fenugreek: Mechanisms of Actions and Potential Effects on Metabolic Syndrome. Advances Nutrition, 2015, 6 (2), 189-197.

  18. Ganjali, S.; Sahebkar, A.; Mahdipour, E.; Jamialahmadi, K.; Torabi, S.; Akhlaghi, S.; Ferns, G.; Parizadeh, S.M.R.; Ghayour-Mobarhan, M. Investigation of the Effects of Curcumin on Serum Cytokines in Obese Individuals: A Randomized Controlled Trial. The Scientific World Journal, 2014, 2014 (ID: 898361), 1-6.

  19. Ghorbani, A.; Hadjzadeh, M. A.; Rajaei, Z.; Zendehbad, S. B. Effects of Fenugreek Seeds on Adipogenesis and Lipolysis in Normal and Diabetic Rats. Pakistan Journal of Biological Sciences, 2014, 17 (4), 523-528.

  20. Giri, J.; Sakthidevi, T. K.; Meerarani, S. Effect of Ginger on Serum Cholesterol Levels. Indian Journal of Nutrition and Dietetics, 1984, 21 (12), 433-436.

  21. Golden, S. H.; Maguire, A.; Ding, J.; Crouse, J. R.; Cauley, J. A.; Zacur, H.; Szklo, M. Endogenous Postmenopausal Hormones and Carotid Atherosclerosis: A Case Study of The Atherosclerosis Risk in Communities Cohort. American Journal of Epidemiology, 2002, 155 (5), 437-445.

  22. Jana, S.; Patra, K.; Sarkar, S.; Jana, J.; Mukherjee, G.; Bhattacharjee, S.; Mandal, D.P. Antitumorigenic Potential of Linalool is Accompanied by Modulation of Oxidative Stress: An In VivoStudy in Sarcoma-180 Solid Tumor Model. Nutrition and Cancer, 2014, 66 (5), 835-848.

  23. Jang, E. M.; Choi, M. S.; Jung, U. J.; Kim, M. J.; Kim, H.J.; Jeon, S.M.; Shin, S.K.; Seong, C.N.; Lee, M.K. Beneficial Effects of Curcumin on Hyperlipidemia and Insulin Resistance In High-Fat-Fed Hamsters. Metabolism, 2008, 57 (11), 1576-1583.

  24. Joshi, S. C.; Sharma, N.; Sharma, P. Antioxidant and Lipid Lowering Effects of Coriandrum sativum in Cholesterol Fed Rabbits. International Journal of Pharmacy and Pharmaceutical Sciences, 2012, 4 (3), 231-234.

  25. Jun, H. J.; Lee, J. H.; Kim, J.; Jia, Y.; Kim, K. H.; Hwang, K. Y.; Yun, E. J.; Do, K. R.; Lee, S. J. Linalool is a PPAR-Α Ligand That Reduces Plasma TG Levels and Rewires The Hepatic Transcriptome and Plasma Metabolome. Journal of Lipid Research, 2014, 55 (6), 1098-1110.

  26. Kaur, J. Comprehensive Review on Metabolic Syndrome. Cardiology Research and Practice, 2014, 2014, 23-37.

  27. Keservani, R. K.; Kesharwani, R. K.; Vyas, N.; Jain, S.; Raghuvanshi, R.; Sharma, A. K. Nutraceutical and Functional Food as Future Food: A Review. Der Pharmacia Lettre (The Pharmacy Letters), 2010, 2 (1), 106-116.

  28. Khoja, K. K.; Shaf, G.; Tarique, N. H.; Naveed, A. S.; Abdrohman, S. A.; Abdullah, H. A.; Ali, A. Fenugreek, A Naturally Occurring Edible Spice, Kills MCF-7 Human Breast Cancer Cells Via an Apoptotic Pathway. Asian Pacific Journal of Cancer Prevention, 2011, 12 (12), 3299-3304.

  29. Kim, S. G.; Veena, M. S.; Basak, S. K.; Han, E.; Tajima, T.  Curcumin Treatment Suppresses IKK-Beta Kinase Activity of Salivary Cells of Patients with Head and Neck Cancer: A Pilot Study. Clinical Cancer Research, 2011, 17, 5953-5961.

  30. Kim, J.; Ha, H. L.; Moon, H. B.; Lee, Y. W.; Cho, C.K.; Yoo, H.S.; Yu, D.Y. Chemopreventive Effect of Curcuma Longa Linn on Liver Pathology in Hbx Transgenic Mice. Integrated Cancer Therapy, 2011, 10, 168-177.

  31. Koupý, D.; Kotolova, H.; Rudá, K. Effectiveness of Phytotherapy in Supportive Treatment of Type 2 Diabetes Mellitus, II: Fenugreek. Ceska a. Slovenska Farmacie, 2015, 64 (3), 67-71.

  32. Krup, V.; Prakash, L. H.; Harini, A. Pharmacological Activities of Turmeric (Curcuma Longa Linn): A Review. Journal of Homeopathy and Ayurvedic Medicine, 2013, 2 (133), 2167-1206.

  33. Kunnumakkara, A. B.; Bordoloi, D.; Padmavathi, G.; Monisha, J.; Roy, N. K.; Prasad, S.; Aggarwal, B. B. Curcumin, the Golden Nutraceutical: Multitargeting for Multiple Chronic Diseases. British Journal of Pharmacology, 2017, 174 (11), 1325-1348.

  34. Laribi, B.; Kouki, K.; M' Hamdi, M.; Bettaieb, T. Coriander (Coriandrum sativum L.) and its Bioactive Constituents. Fitoterapia, 2015, 103, 9-26.

  35. Li, F.; Fernandez, P. P.; Rajendran, P.; Hui, K. M.; Sethi, G. Diosgenin, A Steroidal Saponin, Inhibits STAT3 Signaling Pathway Leading to Suppression of Proliferation and Chemo-sensitization of Human Hepatocellular Carcinoma Cells. Cancer Letters, 2010, 292 (2), 197-207.

  36. Li, Y.; Tran, V. H.; Duke, C. C.; Roufogalis, B. D. Preventive and Protective Properties of Zingiber officinale (Ginger) in Diabetes Mellitus, Diabetic Complications, and Associated Lipid and Other Metabolic Disorders: A Brief Review. Evidence-Based Complementary and Alternative Medicine, 2012, 2012 (ID: 516870), 1-10.

  37. Li, Y.; Tran, V. H.; Duke, C.C.; Roufogalis, B. D. Gingerols of Zingiber OfficinaleEnhance Glucose Uptake by Increasing Cell Surface GLUT4 in Cultured L6 Myotubes. Planta Medica, 2012, 78 (14), 1549-1555.

  38. Misawa, K.; Hashizume, K.; Yamamoto, M.; Minegishi, Y.; Hase, T.; Shimotoyodome, A. Ginger Extract Prevents High-Fat Diet-Induced Obesity in Mice Via Activation of the Peroxisome Proliferator-Activated Receptor Δ Pathway. The Journal of Nutritional Biochemistry, 2015, 26 (10), 1058-1067.

  39. Moorthy, R.; Prabhu, K. M.; Murthy, P. S. Anti-Hyperglycemic Compound (GII) From Fenugreek Seeds, its Purification and Effect in Diabetes Mellitus. Indian J. Exp. Biology, 2010, 48 (11), 1111-1118.

  40. Moosa, Abu, S. M.; Mamun, U. R.; Asadi, A. Z. S.; Nazma, A. M.; Mojib, U.; Ferdaus, A. Hypolipidemic Effects of Fenugreek Seed Powder. Bangladesh Journal of Pharmacology, 2006, 1 (2), 64-67.

  41. Murugesan, M.; Ramalingam, R.; Vaiyapuri, M. Cardioprotective Effect of Fenugreek on Isoproterenol-Induced Myocardial Infarction in Rats. Indian Journal of Pharmacology, 2011, 43 (5), 516.

  42. Nagabhushan, M.; Amonkar, A. J.; Bhide, S. V. Mutagenicity of Gingerol and Shogaol and Antimutagenicity of Zingerone in Salmonella/Microsome Assay. Cancer Letters, 1987, 36 (2), 221-233.

  43. Nyakudya, T.; Siyanda, M.; Nompilo, M.; Kennedy, E. Dietary Supplementation with Coriander Seed: Effect on Growth Performance, Circulating Metabolic Substrates, and Lipid Profile of The Liver and Visceral Adipose Tissue in Healthy Female Rats. International Journal of Agriculture and Biology, 2014, 16, 1-9.

  44. Panda, S.; Sagarika, B.; Anand, K. Trigonelline Isolated from Fenugreek Seed Protects Against Isoproterenol-Induced Myocardial Injury Through Down-Regulation of Hsp27 and αβ-crystallin. Nutrition, 2013, 29 (11), 1395-1403.

  45. Prasad, S.; Tyagi, A. K. Ginger and its constituents: role in prevention and treatment of gastrointestinal cancer. Gastroenterology Research and Practice, 2015, 2015 (ID: 142979), 1-11.

  46. Raju, J.; Gupta, D.; Rao, A. R.; Yadava, P. K.; Baquer, N. Z. Trigonella foenum graecum (fenugreek) Seed Powder Improves Glucose Homeostasis in Alloxan Diabetic Rat Tissues by Reversing the Altered Glycolytic, Gluconeogenic and Lipogenic Enzymes. Molecular and Cellular Biochemistry, 2001, 224 (1-2), 45-51.

  47. Ramadan, M. F.; Amer, M. M. A.; Awad, A. E. S. Coriander (Coriandrum sativumL.) Seed Oil Improves Plasma Lipid Profile in Rats Fed A Diet Containing Cholesterol. European Food Research and Technology, 2008, 227 (4), 1173-1182.

  48. Ramulu, P.; Nappan, V. G.; Paruchuri, U. Hypolipidemic Effect of Soluble Dietary Fiber (Galactomannan) Isolated from Fenugreek Seeds in WNIN (GR-Ob) Obese Rats. Journal of Medicinal Plants Research, 2011, 5 (19), 4804-4813.

  49. Rani, M. P.; Krishna, M. S.; Padmakumari, K. P.; Raghu, K. G.; Sundaresan, A. Zingiber officinale Extract Exhibits Antidiabetic Potential Via Modulating Glucose Uptake, Protein Glycation and Inhibiting Adipocyte Differentiation: An In Vitro Study. Journal of the Science of Food and Agriculture, 2012, 92 (9), 1948-1955.

  50. Sahebkar, A.; Mohammadi, A.; Atabati, A.; Rahiman, S.; Tavallaie, S.; Iranshahi M. Curcuminoids Modulate Pro-Oxidant-Antioxidant Balance but Not the Immune Response to Heat Shock Protein 27 and Oxidized LDL in Obese Individuals. Phytotherapy Research, 2013, 27, 1883-1888.

  51. Saraswat, M.; Suryanarayana, P.; Reddy, P. Y.; Patil, M. A.; Balakrishna, N.; Reddy, G. B. Anti-glycating Potential of Zingiber Officinalis and Delay of Diabetic Cataract in Rats. Molecular Vision, 2010, 16, 1525–1537.

  52. Sebastian, K. S.; Raghava, V. T. Differential Effects of Soybean and Fenugreek Extracts on the Growth of MCF-7 Cells. Chemico - Biological Interactions, 2007, 170 (2), 135-143.

  53. Seyfried, T. N.; Shelton, L. M. Cancer as a Metabolic Disease. Nutrition and Metabolism, 2010, 7 (7), 1-22.

  54. Shamoto, T.; Matsuo, Y.; Shibata, T.; Tsuboi, K.; Nagasaki, T.; Takahashi, H.; Funahashi, H.; Okada, Y.; Takeyama, H. Zerum Bone Inhibits Angiogenesis by Blocking NF-Κb Activity in Pancreatic Cancer. Pancreas, 2014, 43 (3), 396-404.

  55. Singletary, K. Coriander: Overview of Potential Health Benefits. Nutrition Today, 2016, 51 (3), 151-161.

  56. Smith, M. Therapeutic Applications of Fenugreek. Alternative Medicine Review, 2003, 8 (1), 20-27.

  57. Song, B. L.; De Bose-Boyd, R. A. Insig-Dependent Ubiquitination and Degradation Of 3-hydroxy-3-methylglutaryl Coenzyme A Reductase Stimulated by δ-and γ-tocotrienols. Journal of Biological Chemistry, 2006, 281 (35), 25054-25061.

  58. Srinivasan, K. Role of Spices Beyond Food Flavoring: Nutraceuticals with Multiple Health Effects. Food Reviews International, 2005, 21 (2), 167-188.

  59. Srinivasan, K. Ginger (Zingiber officinale): A Spice with Multiple Health Beneficial Potentials. Pharma Nutrition, 2017, 5 (1), 18-28.

  60. Suchankova, G. M.; Tekle, A. K.; Saha, N. B.; Ruderman, S. D.; Clarke; Gettys, T. W. Dietary Polyunsaturated Fatty Acids Enhance Hepatic AMP-Activated Protein Kinase Activity in Rats. Biochemical and Biophysical Research Communications, 2005, 326, 851-858

  61. Suchitra, M. R.; Parthasarathy, S. Effect of Administration of Fenugreek Seeds on Hba1c Levels in Uncontrolled Diabetes Mellitus–A Randomized Controlled Trial. International Journal of Pharm Tech Research, 2015, 8 (2), 180-182.

  62. Tang, E. L.; Rajarajeswaran, J.; Fung, S. Y.; Kanthimathi, M. Antioxidant Activity of Coriandrum Sativum and Protection Against DNA Damage and Cancer Cell Migration. BMC Complementary and Alternative Medicine, 2013, 13, 347-360.

  63. Uemura, T.; Tsuyoshi, G.; Min-Sook, K.; Noriko, M.; Shizuka, H.; Joo-Yong, L.; Yuki, N. Diosgenin, the Main Aglycon of Fenugreek, Inhibits LXRα Activity in HepG2 Cells and Decreases Plasma and Hepatic Triglycerides in Obese Diabetic Mice–3. Journal of Nutrition, 2010, 141 (1), 17-23.

  64. Vijayakumar, M. V.; Vimal, P.; Gyan, C. M.; Manoj, K. B. Hypolipidemic Effect of Fenugreek Seeds is Mediated Through Inhibition of Fat Accumulation and Up Regulation of LDL Receptor. Obesity, 2010, 18 (4), 667-674.

  65. White, B. Ginger: An Overview. American Family Physician, 2007, 75 (11), 1689-1691.

  66. Wilken, R. Curcumin: A Review of Anti-Cancer Properties and Therapeutic Activity in Head and Neck Squamous Cell Carcinoma. Molecular Cancer, 2011, 10 (12), 1-19.

  67. Wilson, P. W.; D’ Agostino, R. B.; Parise, H.; Sullivan, L.; Meigs, J. B. Metabolic Syndrome as a Precursor of Cardiovascular Disease and Type 2 Diabetes Mellitus. Circulation, 2005, 112 (20), 3066-3072.

  68. Wongcharoen, W.; Phrommintikul, A. The Protective Role of Curcumin in Cardiovascular Diseases. International Journal of Cardiology, 2009, 133 (2), 145-151.

  69. Wongcharoen, W.; Jai-Aue, S.; Phrommintikul, A.; Nawarawong, W.; Woragidpoonpol, S.; Tepsuwan, T. Effects of Curcuminoids on Frequency of Acute Myocardial Infarction After Coronary Artery Bypass Grafting. American Journal of Cardiology, 2012, 110, 40- 44.

  70. Yang, Y. S.; Su, Y. F.; Yang, H. W.; Lee, Y. H.; Chou, J. I.; Ueng, K. C. Lipid‐Lowering Effects of Curcumin in Patients with Metabolic Syndrome: A Randomized, Double-Blind, Placebo‐Controlled Trial. Phytotherapy Research, 2014, 28, 1770-1777.

  71. Zhang, Y.; Yang, C.; Wang, W.; Liu, J.; Liu, Q.; Huang, F.; Chu, L.; Gao, H.; Li, C.; Kong, D.; Liu, Q. Co-Delivery of Doxorubicin and Curcumin by pH-Sensitive Prodrug Nanoparticle for Combination Therapy of Cancer. Scientific Reports, 2016, 6 (1), 1-12.

Funding Information

Uma Maheshwari is thankful to DBT, New Delhi, for the Junior Research Fellowship.

Declaration of Conflict

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.